|
| 產地 | 進口、國產 |
| 品牌 | 上海莼試 |
| 保存條件 | Store at -20 °C |
| 貨號 | CS12118 |
| 應用范圍 | WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 |
| CAS編號 | |
| 抗體名 | Anti-SIP1 |
| 克隆性 | 是 |
| 靶點 | 詳見說明書 |
| 適應物種 | 詳見說明書 |
| 形態(tài) | 詳見說明書 |
| 宿主 | 詳見說明書 |
| 亞型 | IgG |
| 標識物 | 詳見說明書 |
| 濃度 | 1mg/1ml% |
| 免疫原 | KLH conjugated synthetic peptide derived from human SIP1 |
Smad蛋白相互作用蛋白1抗體規(guī)格 英文名稱 Anti-SIP1
中文名稱 Smad蛋白相互作用蛋白1抗體規(guī)格
別 名 Smad Interacting Protein 1 SIP 1; SIP1 SIP-1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; ZEB2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobox protein 1b.
產品屬性：
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Horse
產品類型 一抗
研究領域 心 細胞生物 發(fā)育生物學 神經生物學 干細胞 細胞周期蛋白 轉錄調節(jié)因子 表觀遺傳學
蛋白分子量 predicted molecular weight: 136kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SIP1
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Smad蛋白相互作用蛋白1抗體規(guī)格 產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.
Function : Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
Subunit : Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity). Interacts with CBX4 and CTBP1.
Subcellular Location : Nucleus.
Post-translational modifications : Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.
DISEASE : Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS) [MIM:235730]; also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes.
Similarity : Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Contains 7 C2H2-type zinc fingers.
Contains 1 homeobox DNA-binding domain.
實驗流程：
全、新、優(yōu)、品、好四大特點：
Smad蛋白相互作用蛋白1抗體規(guī)格 全：公司提供上萬種產品，涵蓋了生物試劑，elisa試劑盒，標準品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細胞等，基本上各種科研所需產品在我司都能找到。
新：產品更新速度較快，基本上每周都有新產品出現。
優(yōu)：產品質量好，投訴比較少。
好：我公司具有優(yōu)質的技術團隊，產品一旦售出，實驗過程中遇到困難可提供在線技術咨詢。使您使用產品時沒有任何的后顧之憂。
正在熱銷的相關產品：
EMA(Human Epithelial membrane antigen) ELISA Kit 人上皮膜抗原Multi-class antibodies規(guī)格： 48T
Anti-PKC alpha 蛋白激酶C α抗體Multi-class antibodies規(guī)格： 0.2ml
Rhesus antibody Rh HIDE1/C19orfC38 19號染色體開放閱讀框38抗體 規(guī)格 0.2ml
PsmAb(Human anti-presynaptic membrane antibody) ELISA Kit 人抗突觸前膜抗體 96T
PPP2R3 英文名稱： 蛋白質磷酸酶2A亞基3抗體 0.2ml
CXXC5 英文名稱： 二硫鍵氧化還原酶鋅指蛋白5抗體 0.2ml
Anti-PKC alpha 蛋白激酶C α抗體Multi-class antibodies規(guī)格： 0.2ml
Anti-C-Mer/MERTK /FITC 熒光素標記c-mer原癌基因酪氨酸激酶抗體IgGMulti-class antibodies規(guī)格： 0.2ml
Anti-Integrin Alpha6/CD49f/VLA-6/FITC 熒光素標記整合素α6抗體IgGMulti-class antibodies規(guī)格： 0.2ml
Rhesus antibody Rh CCDC75 卷曲螺旋結構域蛋白75抗體 規(guī)格 0.2ml
HO-1/HSP32(Hemeo xygenase 1) 血紅素氧合酶-1/熱休克蛋白-32抗原 0.5mg
hnRNP L 英文名稱： 異質核糖核蛋白L抗體 0.2ml
Rhesus antibody Rh SNX27 SNX27蛋白抗體 規(guī)格 0.2ml
Anti-Integrin Alpha6/CD49f/VLA-6/FITC 熒光素標記整合素α6抗體IgGMulti-class antibodies規(guī)格： 0.2ml
GSTs(Human glutathione S-transferases) ELISA Kit 人谷胱甘肽S轉移酶Multi-class antibodies規(guī)格： 48T
Anti-GLUR3/GRIA 3 谷氨酸受體3抗體Multi-class antibodies規(guī)格： 0.2ml
Rhesus antibody Rh IGFBP6 樣生長因子結合蛋白6抗體 規(guī)格 0.2ml
Beta-TG ELISA Kit 大鼠β血小板球蛋白/β環(huán)蛋白 96T
phospho-PTPRA (Ser180) 英文名稱： 磷酸化酪酸磷酸酶α抗體 0.1ml
Chondrocalcin 英文名稱： Ⅱ型膠原α1蛋白/軟骨鈣素抗體 0.1ml
Anti-GLUR3/GRIA 3 谷氨酸受體3抗體Multi-class antibodies規(guī)格： 0.2ml
BST1 Others Rat 大鼠 CD157 / BST1 人細胞裂解液 (陽性對照)
人小氣道上皮細胞總RNAHSAEpiC NA
人骨骼肌細胞完全培養(yǎng)基 100mL
CHO-AA8細胞，轉入Tet-off調控含EGFP基因的CHO細胞 H9c2(2-1)(大鼠心肌細胞) 615小鼠前瘤株;Fc
EFNB2 Protein Canine 重組狗 Ephrin-B2 / EFNB2 蛋白 (Fc 標簽)
U-87 MG(人神經細胞) 5×106cells/瓶×2 小鼠樹突狀細胞細胞;DCS
CM-H006人肺動脈成纖維細胞完全培養(yǎng)基100mL
WARS Others Human 人 WARS / pRS 桿狀病毒-昆蟲細胞裂解液 (陽性對照)
原代上皮細胞特制基礎培養(yǎng)基Many types of cells包裝：500/250/100ml
恒河猴腎細胞;MMK3 人淋巴樣Butt細胞，EB-3[EB3]細胞 TE-11(細胞)
人急性早幼粒細胞;HL-60
EFNA3 Others Human 人 EphrinA3 / EFNA3 人細胞裂解液 (陽性對照)
Smad蛋白相互作用蛋白1抗體規(guī)格 CM-H004人肺大內皮細胞完全培養(yǎng)基100mL
SUSD4 Others Human 人 SUSD4 / Sushi domain-coaining 人細胞裂解液 (陽性對照)
原代軟骨細胞特制基礎培養(yǎng)基Many types of cells包裝：500/250/100ml
DU145細胞，人細胞 人癌細胞,LCC1細胞 間充質干細胞培養(yǎng)基MSCM-acf-prf
婆羅門牛皮膚成纖維樣細胞;BOS-4
IL2RG Others Mouse 小鼠 IL2RG 人細胞裂解液 (陽性對照)
技術外包服務:
★Smad蛋白相互作用蛋白1抗體規(guī)格 分子生物學：質粒抽提、PCR、Q-PCR、RT-PCR、分子生物學：基因合成、引物合成、基因測序、載體構建等
★蛋白工程：原核、哺乳動物蛋白表達系統等
★病毒包裝：腺病毒、慢病毒等
★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等
★細胞工程：細胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復、克隆形成)、細胞培養(yǎng)、細胞膜制備、穩(wěn)定細胞株構建、細胞RNAi技術等等。
