|
| 產地 | 進口、國產 |
| 品牌 | 上海莼試 |
| 保存條件 | Store at -20 °C |
| 貨號 | CS11442 |
| 應用范圍 | WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 |
| CAS編號 | |
| 抗體名 | Anti-SLC4A4 |
| 克隆性 | |
| 靶點 | 詳見說明書 |
| 適應物種 | 詳見說明書 |
| 形態(tài) | 詳見說明書 |
| 宿主 | 詳見說明書 |
| 亞型 | IgG |
| 標識物 | 詳見說明書 |
| 濃度 | 1mg/1ml% |
| 免疫原 | KLH conjugated synthetic peptide derived from human SLC4A4 |
碳酸氫鈉協(xié)同轉運蛋白4-A4抗體規(guī)格 英文名稱 Anti-SLC4A4
中文名稱 碳酸氫鈉協(xié)同轉運蛋白4-A4抗體規(guī)格
別 名 DKFZp781H1314; Electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC 1; HNBC1; kNBC 1; KNBC; kNBC1; Na(+)/HCO3(-) cotransporter; Na+HCO3- cotransporter 4; NBC 1; NBC 2; NBC1; NBC2; Nbc4; NBCE 1; NBCE1; PNBC; SLC4A5; Sodium bicarbonate cotransporter kidney; sodium bicarbonate cotransporter member 4; Sodium bicarbonate cotransporter pancreas; Solute carrier family 4 member 4; solute carrier family 4 sodium bicarbonate cotransporter member 4; Solute carrier family 4 sodium bicarbonate cotransporter member 5.
產品屬性：
濃 度 1mg/1ml
規(guī) 格 0.1ml/100μg 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep
產品類型 一抗
研究領域
蛋白分子量 predicted molecular weight: 119kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SLC4A4
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
碳酸氫鈉協(xié)同轉運蛋白4-A4抗體規(guī)格 產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 SLC4A4 (Electrogenic sodium bicarbonate cotransporter 1) is an electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. It may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. SLC4A4 interacts with carbonic anhydrase 2 and carbonic anhydrase 4 which may regulate transporter activity. There are four named isoforms produced by alternative splicing.
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Function : Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Subunit : Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity.
Subcellular Location : Basolateral cell membrane; Multi-pass membrane protein.
Tissue Specificity : Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.
Post-translational modifications : Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylation of Thr-49 regulates isoform 1 conductance.
N-glycosylation is not necessary for the transporter basic functions.
DISEASE : Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA) [MIM:604278]; also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy.
Note=Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17).
Similarity : Belongs to the anion exchanger (TC 2.A.31) family.
Database links : UniProtKB/Swiss-Prot: Q9Y6R1.1
實驗流程：
全、新、優(yōu)、品、好四大特點：
碳酸氫鈉協(xié)同轉運蛋白4-A4抗體規(guī)格 全：公司提供上萬種產品，涵蓋了生物試劑，elisa試劑盒，標準品，培養(yǎng)基，原裝耗材，抗體、培養(yǎng)基、ATCC細胞等，基本上各種科研所需產品在我司都能找到。
新：產品更新速度較快，基本上每周都有新產品出現。
優(yōu)：產品質量好，投訴比較少。
好：我公司具有優(yōu)質的技術團隊，產品一旦售出，實驗過程中遇到困難可提供在線技術咨詢。使您使用產品時沒有任何的后顧之憂。
正在熱銷的相關產品：
Anti-SLT/SLT-IIe(O139) /FITC 熒光素標記抗豬素(O139)抗體IgGMulti-class antibodies規(guī)格： 0.2ml
Caspase-6 (NT) 半胱胺酸蛋白酶蛋白-6(抗原)Multi-class antibodies規(guī)格： 0.5mg
神經纖毛蛋白-2抗體 Anti-NRP-2 0.1ml
SOSSC 英文名稱： 單鏈DNA結合蛋白相互作用蛋白1 0.2ml
EMAP2 英文名稱： 內皮單核細胞激活肽2抗體 0.2ml
Rhesus antibody Rh phospho-ODF2(Ser796) 磷酸化尾部結構蛋白抗體 規(guī)格 0.1ml
Caspase-6 (NT) 半胱胺酸蛋白酶蛋白-6(抗原)Multi-class antibodies規(guī)格： 0.5mg
Anti-TM/FITC 熒光素標記調節(jié)蛋白抗體IgGMulti-class antibodies規(guī)格： 0.2ml
OPN 骨橋蛋白(多肽抗原)Multi-class antibodies規(guī)格： 0.5mg
轉移生長因子–β受體1抗體 Anti-TGF-βR1/ALK 0.1ml
SKP1 英文名稱： S期激酶相關蛋白1抗體 0.2ml
alpha Elastin 英文名稱： α彈性蛋白抗體 0.1ml
Rhesus antibody Rh Phospho-LAT (Tyr191) 磷酸化T細胞活化連接蛋白抗體 規(guī)格 0.1ml
OPN 骨橋蛋白(多肽抗原)Multi-class antibodies規(guī)格： 0.5mg
Adiponectin 脂聯素(多肽片斷抗原)Multi-class antibodies規(guī)格： 0.5mg
Anti-B7H4 B7-H4抗體Multi-class antibodies規(guī)格： 0.1ml
Rhesus antibody Rh Phospho-Ack1(Tyr859/860) 磷酸化Ack1抗體 規(guī)格 0.1ml
MAP2a,b 濃縮液 0.1ml 進口分裝
UBF1 英文名稱： RNA聚合酶I抗體 0.1ml
CHST6 英文名稱： 碳水化合物磺基轉移酶6抗體 0.1ml
Anti-B7H4 B7-H4抗體Multi-class antibodies規(guī)格： 0.1ml
IL17A Protein Human 重組人 IL17 / IL17A 蛋白 (His 標簽)
小鼠虹膜色素上皮細胞完全培養(yǎng)基 100mL
B2M Others Mouse 小鼠 B2M / Beta-2-microglobulin 人細胞裂解液 (陽性對照)
L1210小鼠細胞 L1210 mouse leukemia cells DMEM培養(yǎng)基+10%FBS
CM-H100胎兒細胞完全培養(yǎng)基100mL
人膠質細胞(少突細胞)(HO) (1×106 ) 細胞名稱 種屬
CM-H111人成骨細胞完全培養(yǎng)基100mL
PDHA1 Others Human 人 PDHA1 / C54G1 (aa 30-390) 桿狀病毒-昆蟲細胞裂解液 (陽性對照)
人腎上腺皮質細胞HACC
非洲綠猴腎細胞系/IgR;VERO/IgR 大鼠細胞，CBRH-7919細胞 BEL-7405(細胞)
人癌細胞;MCF7
TNFRSF4 Others Human 人 TNFRSF4 / CD134 人細胞裂解液 (陽性對照)
碳酸氫鈉協(xié)同轉運蛋白4-A4抗體規(guī)格 IL17A Protein Human 重組人 IL17 / IL17A 蛋白 (His 標簽)
小鼠虹膜色素上皮細胞完全培養(yǎng)基 100mL
B2M Others Mouse 小鼠 B2M / Beta-2-microglobulin 人細胞裂解液 (陽性對照)
L1210小鼠細胞 L1210 mouse leukemia cells DMEM培養(yǎng)基+10%FBS
CM-H100胎兒細胞完全培養(yǎng)基100mL
人膠質細胞(少突細胞)(HO) (1×106 ) 細胞名稱 種屬
技術外包服務:
★碳酸氫鈉協(xié)同轉運蛋白4-A4抗體規(guī)格 分子生物學：質粒抽提、PCR、Q-PCR、RT-PCR、分子生物學：基因合成、引物合成、基因測序、載體構建等
★蛋白工程：原核、哺乳動物蛋白表達系統(tǒng)等
★病毒包裝：腺病毒、慢病毒等
★抗體工程：磁珠分選、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等
★細胞工程：細胞表型分析(凋亡、增殖、周期、遷移、侵襲、修復、克隆形成)、細胞培養(yǎng)、細胞膜制備、穩(wěn)定細胞株構建、細胞RNAi技術等等。
